Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis
The impact of orthopedic scaffolds on bone defect healing, particularly the late-stage bone remodeling process, is pivotal for the therapeutic outcome. This study applies fadditively manufactured scaffolds composed of hydroxyapatite-doped poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lac...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-02-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004638 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846123347284328448 |
|---|---|
| author | Juncen Zhou Negar Akrami Hanbo Wang Liang Fang Jie Shen Cunjiang Yu Ben Zhang Donghui Zhu |
| author_facet | Juncen Zhou Negar Akrami Hanbo Wang Liang Fang Jie Shen Cunjiang Yu Ben Zhang Donghui Zhu |
| author_sort | Juncen Zhou |
| collection | DOAJ |
| description | The impact of orthopedic scaffolds on bone defect healing, particularly the late-stage bone remodeling process, is pivotal for the therapeutic outcome. This study applies fadditively manufactured scaffolds composed of hydroxyapatite-doped poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (HA-PELGA) with varying properties to treat rat calvarial defects, elucidating their significant role in bone remodeling by modulating physiological responses. We engineered two scaffolds with different polylactic acid (PLA) to polyglycolic acid (PGA) ratio (9/1 and 18/1) to vary in hydrophobicity, degradation rate, mechanical properties, and structural stability. These variations influenced physiological responses, including osteogenesis, angiogenesis, and immune reactions, thereby guiding bone remodeling. Our findings show that the HA-PELGA(18/1) scaffold, with a slower degradation rate, supported bulk bone formation due to a stable microenvironment. Conversely, the HA-PELGA(9/1) scaffold, with a faster degradation rate and more active interfaces, facilitated the formation of a thin bone layer and higher bone infiltration. This study demonstrates these degradable scaffolds help to promote bone healing and reveals how scaffold properties influence the bone remodeling process, offering a potential strategy to optimize scaffold design aiming at late-stage bone defect healing. |
| format | Article |
| id | doaj-art-802ee0ae26f74bd3907c7066a3fda046 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-802ee0ae26f74bd3907c7066a3fda0462024-12-14T06:31:44ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-02-0144371388Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesisJuncen Zhou0Negar Akrami1Hanbo Wang2Liang Fang3Jie Shen4Cunjiang Yu5Ben Zhang6Donghui Zhu7Department of Biomedical Engineering, University of Stony Brook, 100 Nicolls Rd, Stony Brook, NY, 11794, USADepartment of Biomedical Engineering, University of Stony Brook, 100 Nicolls Rd, Stony Brook, NY, 11794, USADepartment of Biomedical Engineering, University of Stony Brook, 100 Nicolls Rd, Stony Brook, NY, 11794, USADepartment of Orthopaedic Surgery, Washington University, St. Louis, MO, 63110, USADepartment of Orthopaedic Surgery, Washington University, St. Louis, MO, 63110, USADepartment of Electrical & Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USADepartment of Biomedical Engineering, University of Stony Brook, 100 Nicolls Rd, Stony Brook, NY, 11794, USA; Corresponding author.Department of Biomedical Engineering, University of Stony Brook, 100 Nicolls Rd, Stony Brook, NY, 11794, USA; Corresponding author.The impact of orthopedic scaffolds on bone defect healing, particularly the late-stage bone remodeling process, is pivotal for the therapeutic outcome. This study applies fadditively manufactured scaffolds composed of hydroxyapatite-doped poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (HA-PELGA) with varying properties to treat rat calvarial defects, elucidating their significant role in bone remodeling by modulating physiological responses. We engineered two scaffolds with different polylactic acid (PLA) to polyglycolic acid (PGA) ratio (9/1 and 18/1) to vary in hydrophobicity, degradation rate, mechanical properties, and structural stability. These variations influenced physiological responses, including osteogenesis, angiogenesis, and immune reactions, thereby guiding bone remodeling. Our findings show that the HA-PELGA(18/1) scaffold, with a slower degradation rate, supported bulk bone formation due to a stable microenvironment. Conversely, the HA-PELGA(9/1) scaffold, with a faster degradation rate and more active interfaces, facilitated the formation of a thin bone layer and higher bone infiltration. This study demonstrates these degradable scaffolds help to promote bone healing and reveals how scaffold properties influence the bone remodeling process, offering a potential strategy to optimize scaffold design aiming at late-stage bone defect healing.http://www.sciencedirect.com/science/article/pii/S2452199X24004638Additive manufacturingPolymer scaffoldsBiodegradableBone defect healingBone remodeling |
| spellingShingle | Juncen Zhou Negar Akrami Hanbo Wang Liang Fang Jie Shen Cunjiang Yu Ben Zhang Donghui Zhu Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis Bioactive Materials Additive manufacturing Polymer scaffolds Biodegradable Bone defect healing Bone remodeling |
| title | Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis |
| title_full | Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis |
| title_fullStr | Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis |
| title_full_unstemmed | Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis |
| title_short | Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis |
| title_sort | enhanced healing of critical sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis |
| topic | Additive manufacturing Polymer scaffolds Biodegradable Bone defect healing Bone remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004638 |
| work_keys_str_mv | AT juncenzhou enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT negarakrami enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT hanbowang enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT liangfang enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT jieshen enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT cunjiangyu enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT benzhang enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis AT donghuizhu enhancedhealingofcriticalsizedbonedefectsusingdegradablescaffoldswithtailoredcompositionthroughimmunomodulationandangiogenesis |