Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma

Recent studies have emphasized the important role of Stat3 activation in a number of human tumors from the viewpoint of its oncogenic and antiapoptotic activity. In this study, we examined the role and related signaling molecules of Stat3 in the carcinogenesis of human cutaneous squamous cell carcin...

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Bibliographic Details
Main Authors: Toshinori Bito, Nahoko Sumita, Masashi Ashida, Arief Budiyanto, Masato Ueda, Masamitsu Ichihashi, Yoshiki Tokura, Chikako Nishigori
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Journal of Skin Cancer
Online Access:http://dx.doi.org/10.1155/2011/874571
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