Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression

Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression

Glioblastoma (GBM) is a highly aggressive brain tumor that infiltrates surrounding brain tissue, profoundly affecting adjacent cortical areas. This study investigates how GBM reshapes the peritumoral cortex by examining plasticity changes in two GBM mouse models. Using optogenetic stimulation, we ob...

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Bibliographic Details
Main Authors: Cristina Spalletti, Marta Scalera, Elisabetta Mori, Sabrin Haddad, Marco Mainardi, Daniele Cangi, Vinoshene Pillai, Elena Parmigiani, Silvia Landi, Matteo Caleo, Eleonora Vannini
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Glioblastoma multiforme
Parvalbumin interneurons
Peritumoral tissue
Inhibitory circuits
Morpho-functional reorganization
Preclinical study
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500213X
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