Toxoplasma gondii ROP18 induces maternal–fetal dysfunction by downregulating CD73 expression on decidual macrophages

Toxoplasma gondii ROP18 induces maternal–fetal dysfunction by downregulating CD73 expression on decidual macrophages

Abstract Background Decidual macrophages (dMφ) are pivotal in maintaining maternal–fetal immune tolerance during normal pregnancy by expressing a range of immune-suppressive molecules, including CD73. It has been demonstrated that Toxoplasma gondii (T. gondii) infection during pregnancy can impair d...

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Bibliographic Details
Main Authors: Jingjing Guo, Xiaohui Wang, Lei Wei, Shuai Li, Junwei Wang, Yan Zhang, Ruohan Yang, Han Zhang, Aiqun Xu, Yuzhu Jiang, Xuemei Hu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Parasites & Vectors
Subjects:
Toxoplasma gondii
ROP18
Decidual macrophage
CD73
Abnormal pregnancy outcome
Online Access:https://doi.org/10.1186/s13071-025-06713-2
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https://doi.org/10.1186/s13071-025-06713-2

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