Synthesis, Crystal Structure, DFT Analysis and Docking Studies of a Novel Spiro Compound Effecting on EGR-1-Regulated Gene Expression

Synthesis, Crystal Structure, DFT Analysis and Docking Studies of a Novel Spiro Compound Effecting on EGR-1-Regulated Gene Expression

The spiro compound, 5,5′-dimethoxy-1,3-bis(3-(trifluoromethyl)phenyl)-3,3a-dihydro-1H-spiro[cyclopenta[a]indene-2,2′-indene]-1′,8(3′H,8aH)-dione (<b>4</b>), was synthesized and identified by NMR spectroscopy, mass spectrometry, and X-ray crystallography. Compound <b>4</b>, C&...

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Bibliographic Details
Main Authors: Soon Young Shin, Euitaek Jung, Youngshim Lee, Ha-Jin Lee, Hyeonhwa Lee, Jinju Yoo, Seunghyun Ahn, Dongsoo Koh
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Crystals
Subjects:
Early Growth Respone-1 (EGR-1)
gene expression
X-ray crystallography
spiro compound
HaCaT keratinocytes
in silico docking
Online Access:https://www.mdpi.com/2073-4352/15/4/338
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