Metabolic interference impairs influenza A virus replication by dampening vRNA synthesis

Abstract For replication, viruses exploit the host cell metabolism for biosynthesis of viral components. Recently, we could show that inhibition of glycolysis interfered with IAV replication by impairing the regulation of the viral polymerase as a transcriptase or replicase. Here, we investigated ho...

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Bibliographic Details
Main Authors: Jens Kleinehr, Chiara Robin Bojarzyn, Michael Schöfbänker, Katharina Daniel, Stephan Ludwig, Eike R. Hrincius
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00090-4
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