The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

Abstract Innate immunity represents the body’s first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate immunity in antitumor defense, beyond its established function in protecting against external pathogen invasion....

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Main Authors: Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Jiewen Wang, Mingjing Peng, Yujuan Zhou, Xiyun Deng, Qianjin Liao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Hematology & Oncology
Subjects:
Innate immunity
cGAS
STING
Cancer immunity
Online Access:https://doi.org/10.1186/s13045-025-01691-5
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https://doi.org/10.1186/s13045-025-01691-5

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