Dysregulated lipid metabolism in a retinal pigment epithelial cell model and serum of patients with age-related macular degeneration

Dysregulated lipid metabolism in a retinal pigment epithelial cell model and serum of patients with age-related macular degeneration

Abstract Background Age-related macular degeneration (AMD) is a leading cause of blindness, characterized by retinal pigment epithelium (RPE) dysfunction, extracellular deposit formation, and disrupted lipid metabolism. Understanding the molecular changes underlying AMD is essential for identifying...

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Main Authors: Ana Álvarez-Barrios, Lydia Álvarez, Pilar Sáenz de Santa María, Montserrat García, Jorge R. Álvarez-Buylla, Rosario Pereiro, Héctor González-Iglesias
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Biology
Subjects:
Multiomics
Ageing
Age-related macular degeneration
Lipid metabolism
Retinal pigment epithelium
Serum
Online Access:https://doi.org/10.1186/s12915-025-02198-8
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https://doi.org/10.1186/s12915-025-02198-8

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