Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

Abstract Common inflammatome gene signatures as well as disease‐specific signatures were identified by analyzing 12 expression profiling data sets derived from 9 different tissues isolated from 11 rodent inflammatory disease models. The inflammatome signature significantly overlaps with known drug t...

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Main Authors: I‐Ming Wang, Bin Zhang, Xia Yang, Jun Zhu, Serguei Stepaniants, Chunsheng Zhang, Qingying Meng, Mette Peters, Yudong He, Chester Ni, Deborah Slipetz, Michael A Crackower, Hani Houshyar, Christopher M Tan, Ernest Asante‐Appiah, Gary O'Neill, Mingjuan Jane Luo, Rolf Thieringer, Jeffrey Yuan, Chi‐Sung Chiu, Pek Yee Lum, John Lamb, Yves Boie, Hilary A Wilkinson, Eric E Schadt, Hongyue Dai, Christopher Roberts
Format: Article
Language:English
Published: Springer Nature 2012-07-01
Series:Molecular Systems Biology
Subjects:
Bayesian network
co‐expression network
inflammatome
inflammatory diseases
key regulators
Online Access:https://doi.org/10.1038/msb.2012.24
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https://doi.org/10.1038/msb.2012.24

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