Multi‐layered stochasticity and paracrine signal propagation shape the type‐I interferon response

Multi‐layered stochasticity and paracrine signal propagation shape the type‐I interferon response

Abstract The cellular recognition of viruses evokes the secretion of type‐I interferons (IFNs) that induce an antiviral protective state. By live‐cell imaging, we show that key steps of virus‐induced signal transduction, IFN‐β expression, and induction of IFN‐stimulated genes (ISGs) are stochastic e...

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Main Authors: Ulfert Rand, Melanie Rinas, Johannes Schwerk, Gesa Nöhren, Melanie Linnes, Andrea Kröger, Michael Flossdorf, Kristóf Kály‐Kullai, Hansjörg Hauser, Thomas Höfer, Mario Köster
Format: Article
Language:English
Published: Springer Nature 2012-05-01
Series:Molecular Systems Biology
Subjects:
bacterial artificial chromosomes
gene expression
interferon regulatory factor‐7
live‐cell microscopy
multi‐scale modelling
Online Access:https://doi.org/10.1038/msb.2012.17
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https://doi.org/10.1038/msb.2012.17

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