6-Paradol mitigates rotenone-induced Parkinson’s disease via shutting TNFR-1/RIPK1/RIPK3/MLKL cascade and enhancement of PPARγ/PGC-1α/TFAM axis

6-Paradol mitigates rotenone-induced Parkinson’s disease via shutting TNFR-1/RIPK1/RIPK3/MLKL cascade and enhancement of PPARγ/PGC-1α/TFAM axis

Abstract Background Zingiber officinale rhizomes (Ginger, Zingiberaceae) are used traditionally in treating various ailments, including neurodegenerative diseases. Therefore, its constituents like 6-paradol may be useful in the management of Parkinson's disease (PD). Moreover, promising molecul...

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Main Authors: Alaa Sirwi, Mostafa A. Rabie, Abdulrahman E. Koshak, Dina A. I. Albadawi, Ali M. El-Halawany, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Hossam M. Abdallah, Nesrine S. El-Sayed
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Ginger
Parkinson’s disease
6-paradol
Necroptosis
Neuroinflammation
PGC-1α
Online Access:https://doi.org/10.1186/s43094-025-00831-5
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https://doi.org/10.1186/s43094-025-00831-5

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