Hydrogen Peroxide Modulates the Timely Activation of Jun and Erk in Schwann Cells at the Injury Site and Is Required for Motor Axon Regeneration

Hydrogen Peroxide Modulates the Timely Activation of Jun and Erk in Schwann Cells at the Injury Site and Is Required for Motor Axon Regeneration

Peripheral nervous system (PNS) neurons, including motor neurons (MNs), possess a remarkable ability to regenerate and reinnervate target muscles following nerve injury. This process is orchestrated by a combination of intrinsic neuronal properties and extrinsic factors, with Schwann cells (SCs) pla...

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Bibliographic Details
Main Authors: Samuele Negro, Chiara Baggio, Marika Tonellato, Marco Stazi, Giorgia D’Este, Aram Megighian, Cesare Montecucco, Michela Rigoni
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
Schwann cells
peripheral nerve regeneration
hydrogen peroxide
ERK1/2
c-Jun
Online Access:https://www.mdpi.com/2073-4409/14/9/671
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