Simulations and active learning enable efficient identification of an experimentally-validated broad coronavirus inhibitor

Abstract Drug screening resembles finding a needle in a haystack: identifying a few effective inhibitors from a large pool of potential drugs. Large experimental screens are expensive and time-consuming, while virtual screening trades off computational efficiency and experimental correlation. Here w...

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Bibliographic Details
Main Authors: Katarina Elez, Tim Hempel, Jonathan H. Shrimp, Nicole Moor, Lluís Raich, Cheila Rocha, Robin Winter, Tuan Le, Stefan Pöhlmann, Markus Hoffmann, Matthew D. Hall, Frank Noé
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62139-5
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