Association of <i>SLCO1B3</i> and <i>SLCO1B1</i> Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients

Association of <i>SLCO1B3</i> and <i>SLCO1B1</i> Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients

<b>Background:</b> Methotrexate (MTX) remains the most commonly prescribed drug used to treat rheumatoid arthritis (RA). Polymorphisms in solute carrier organic anion transporter family member 1B3 (<i>SLCO1B3</i>) and <i>SLCO1B1</i> may play a critical role in MTX...

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Main Authors: Rania Magadmi, Ahlam M. Alharthi, Lina A. Alqurashi, Ibtisam M. Jali, Zeina W. Sharawi, Maha H. Jamal, Yasser Bawazir, Mohammad Mustafa, Sami M. Bahlas, Basma T. Jamal, Hassan Daghasi, Abdulrahman S. Altowairqi, Dalal Sameer Al Shaer
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
methotrexate
personalized medicine
pharmacogenetics
polymorphism
rheumatoid arthritis
single nucleotide polymorphism
Online Access:https://www.mdpi.com/1424-8247/18/7/1069
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