Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING

Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING

Doxorubicin (Dox) is an anthracycline drug widely applied in various malignancies. However, the fatal cardiotoxicity induced by Dox limits its clinical application. Post-transcriptional protein modification via ubiquitination/deubiquitination in cardiomyocytes mediates the pathophysiological process...

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Bibliographic Details
Main Authors: Liming Lin, Jibo Han, Diyun Xu, Zimin Fang, Bozhi Ye, Jinfu Qian, Xue Han, Julian Min, Xiaohong Long, Gaojun Wu, Guang Liang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Deubiquitinating enzyme
USP13
STING
Autophagy
Inflammation
Doxorubicin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002205
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