Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics
Abstract This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant i...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | npj Women's Health |
| Online Access: | https://doi.org/10.1038/s44294-025-00077-9 |
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