Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women

Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women

Introduction Acne is one of the most common inflammatory skin diseases worldwide and can have significant psychosocial impact and cause permanent scarring. Spironolactone, a potassium-sparing diuretic, has antiandrogenic properties, potentially reducing sebum production and hyperkeratinisation in ac...

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Main Authors: Ingrid Muller, Miriam Santer, Beth Stuart, Fay Chinnery, Matthew J Ridd, Karen Thomas, Kim Suzanne Thomas, Gareth Griffiths, Jacqui Nuttall, Tracey Sach, Irene Soulsby, Alison M Layton, Susanne Renz, Laura Day, Louise Stanton, Zina Eminton
Format: Article
Language:English
Published: BMJ Publishing Group 2021-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/8/e053876.full
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https://bmjopen.bmj.com/content/11/8/e053876.full

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