Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site

Abstract Peptidylarginine deiminases (PAD1-4) are calcium dependent enzymes responsible for protein citrullination, a post-translational modification converting arginine residues to citrulline. Elevated levels of citrullinated proteins have been associated with rheumatoid arthritis, neurodegenerativ...

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Main Authors: Leslie A. Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F. Vajdos, Jeffrey W. Pelker, Simeon Ramsey, Paul Balbo, Parag V. Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W. Wright, Jeanne S. Chang, John M. Curto, Jennifer E. Davoren, Susan E. Drozda, Kimberly F. Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L. Lee, Shenping Liu, Frank Lovering, Jennifer A. Nicki, John I. Trujillo, Fabien Vincent, Mark E. Schnute
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59919-4
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https://doi.org/10.1038/s41467-025-59919-4

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