TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen Trypanosoma cruzi

TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen Trypanosoma cruzi

ABSTRACT Trypanosoma cruzi is the causative agent of Chagas disease, a zoonotic infectious disease considered a leading cause of cardiomyopathy, disability, and premature death in the Americas. This parasite spends its life between a mammalian host and an arthropod vector, undergoing essential trans...

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Bibliographic Details
Main Authors: Joshua Carlson, Milad Ahmed, Riley Hunter, Syeda Farjana Hoque, Joshua B. Benoit, Miguel A. Chiurillo, Noelia Lander
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
adenylate cyclase
Chagas disease
contractile vacuole complex
flagellar distal domain
kissing bugs
metacyclogenesis
Online Access:https://journals.asm.org/doi/10.1128/mbio.00994-25
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https://journals.asm.org/doi/10.1128/mbio.00994-25

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