Single Cell Transcriptomic Profiling of MYBPC3‐Associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process But Not Gene Expression

Single Cell Transcriptomic Profiling of MYBPC3‐Associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process But Not Gene Expression

Background Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease where the most frequently associated mutations occur in the myosin‐binding protein C (MYBPC3) sarcomere‐associated gene. HCM is also a common veterinary clinical problem in certain cat breeds such as Maine Coons and Rag...

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Bibliographic Details
Main Authors: Samia A. Ali, Gayani Perera, Jason Laird, Rebecca Batorsky, Martin S. Maron, Victor N. Rivas, Joshua A. Stern, Samantha Harris, Michael T. Chin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
differential gene expression
feline cardiomyopathies
gene ontology enrichment analysis
hypertrophic cardiomyopathy
myosin‐binding protein C
sarcomere
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035780
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https://www.ahajournals.org/doi/10.1161/JAHA.124.035780

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