An overview of hereditary spherocytosis and the curative effects of splenectomy

An overview of hereditary spherocytosis and the curative effects of splenectomy

Hereditary spherocytosis is a common hemolytic anemia with different severity. The causes of hereditary spherocytosis are mutations in genes that encode red blood cell (RBC) membrane and cytoskeletal proteins, including ankyrin-1, Band 3 (or AE1), α spectrin, β spectrin, and protein 4.2. Molecular d...

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Main Authors: Kyril Turpaev, Elizaveta Bovt, Soslan Shakhidzhanov, Elena Sinauridze, Nataliya Smetanina, Larisa Koleva, Nikita Kushnir, Anna Suvorova, Fazoil Ataullakhanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Physiology
Subjects:
hereditary spherocytosis
gene mutations
erythrocyte cytoskeleton
erythrocyte deformability
spherocytes
microcirculation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1497588/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1497588/full

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