Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway

Nicotinamide mononucleotide ameliorates ionizing radiation-induced spermatogenic dysfunction in mice by modulating the glycolytic pathway

Radiotherapy, a common cancer treatment, leads to infertility in male cancer survivors, particularly young and middle-aged patients. Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD<sup>+</sup>), plays crucial roles in energy metabolism, DNA repair...

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Main Authors: Yang Wenqin, Nong Weihua, Liu Ke, Lei Xiaocan, Chen Xiaping, Jiang Pei, Tang Jiayi, Hu Cong, Hu Zecheng, Li Meixiang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-10-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
ionizing radiation
nicotinamide mononucleotide
spermatogenic dysfunction
glycolysis
apoptosis
sertoli cell
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024167
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https://www.sciengine.com/doi/10.3724/abbs.2024167

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