Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology

Puumala orthohantavirus (PUUV) is an emerging zoonotic virus that was first discovered in the Puumala region of Finland in the early 1980s and is the primary etiological agent of nephropathia epidemica (NE), a milder form of a life-threatening disease known as hemorrhagic fever with renal syndrome (...

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Bibliographic Details
Main Authors: Alina Tscherne, Pablo Guardado-Calvo, Jordan J. Clark, Robert Krause, Florian Krammer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575112/full
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