Oncogene-Induced Senescence Transcriptomes Signify Premalignant Colorectal Adenomas

Oncogene-Induced Senescence Transcriptomes Signify Premalignant Colorectal Adenomas

<b>Background:</b> Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism that halts uncontrolled cell proliferation in premalignant lesions. Further investigation into its role in colorectal tumorigenesis is essential. We investigated the expression of OIS transcriptomic lan...

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Bibliographic Details
Main Authors: Sofian Al Shboul, Heyam Awad, Anas Abu-Humaidan, Nidaa A. Ababneh, Ashraf I. Khasawneh, Tareq Saleh
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Current Issues in Molecular Biology
Subjects:
oncogene-induced senescence (OIS)
senescence-associated secretory phenotype (SASP)
colorectal cancer
adenoma
single-sample gene set enrichment analysis (ssGSEA)
Online Access:https://www.mdpi.com/1467-3045/47/4/221
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