Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis

Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis

Abstract Background Cancer-targeted therapies are progressively pivotal in oncological care. Observational studies underscore the emergence of cancer therapy-related cardiovascular toxicity (CTR-CVT), impacting patient outcomes. We aimed to investigate the causal relationship between different types...

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Main Authors: Chuchun Fang, Xuewei Liu, Chen Yu, Songlin Li, Xueying Liu, Shifeng Qiu, Hongbin Liang, Caiwen Ou, Jiancheng Xiu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Cancer-targeted therapy
Cardiovascular diseases
Mendelian randomization
eQTL
Online Access:https://doi.org/10.1186/s12967-024-06027-4
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https://doi.org/10.1186/s12967-024-06027-4

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