Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis.

Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis.

The endoribonuclease (EndoU) nsp15 of coronaviruses plays a crucial role in evading host innate immune responses by reducing the abundance of viral double-stranded RNA (dsRNA). However, our understanding of its interactions with host cellular targets remains limited. In this study, we demonstrate th...

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Main Authors: Xiaoqian Gong, Shanhuan Feng, Jiehuang Wang, Bo Gao, Wenxiang Xue, Hongyan Chu, Shouguo Fang, Yanmei Yuan, Yuqiang Cheng, Min Liao, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Edwin Tijhaar, Maria Forlenza, Ying Liao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012987
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https://doi.org/10.1371/journal.ppat.1012987

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