CSF1R inhibitor (PLX3397) alleviates experimental periodontitis by reducing macrophage senescence through the PI3K/AKT/FOXO1 signaling pathway

CSF1R inhibitor (PLX3397) alleviates experimental periodontitis by reducing macrophage senescence through the PI3K/AKT/FOXO1 signaling pathway

Abstract Macrophage senescence is closely associated with the progression of periodontitis. In vitro investigations have demonstrated that the colony-stimulating factor 1 receptor (CSF1R) inhibitor, PLX3397, reduces macrophage senescence; however, the underlying mechanisms remain unclear. This study...

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Bibliographic Details
Main Authors: Jiabing Kang, Jifan Zhan, Yiting Yuan, Yan Wei, Tianjiao Xiao, Li Li, Hui Fang, Ai Tian
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Colony-stimulating factor 1 receptor (CSF1R)
Macrophage senescence
Periodontitis
PLX3397
PI3K/AKT/FOXO1
Online Access:https://doi.org/10.1038/s41598-025-13153-6
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https://doi.org/10.1038/s41598-025-13153-6

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