Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and...

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Main Authors: Iben Lundgaard, Aryna Luzhynskaya, John H Stockley, Zhen Wang, Kimberley A Evans, Matthew Swire, Katrin Volbracht, Hélène O B Gautier, Robin J M Franklin, Charles Ffrench-Constant, David Attwell, Ragnhildur T Káradóttir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-12-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001743&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001743&type=printable

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