Mechanism of the blood-brain barrier modulation by cadherin peptides

Mechanism of the blood-brain barrier modulation by cadherin peptides

Aim: This study was aimed at finding the binding site on the human E-cadherin for Ala-Asp-Thr Cyclic 5 (ADTC5), ADTC7, and ADTC9 peptides as blood-brain barrier modulator (BBBM) for determining their mechanism of action in modulating the blood-brain barrier (BBB). Methods: ADTC7 and ADTC9 were deriv...

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Main Authors: Elinaz Farokhi, Ahmed L. Alaofi, Vivitri D. Prasasty, Filia Stephanie, Marlyn D. Laksitorini, Krzysztof Kuczera, Teruna J. Siahaan
Format: Article
Language:English
Published: Open Exploration 2024-06-01
Series:Exploration of Drug Science
Subjects:
ala-asp-thr peptides
blood-brain barrier
blood-brain barrier modulator
cadherin peptides
trans-cadherin interaction
nmr
molecular docking
Online Access:https://www.explorationpub.com/uploads/Article/A100849/100849.pdf
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https://www.explorationpub.com/uploads/Article/A100849/100849.pdf

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