Sodium nitroprusside improves circulatory failure in rabbit acute pulmonary embolism combined with shock model possibly by enhancing NO release and inhibiting TLR4/NF-кB/HIF-1α signaling pathway

Sodium nitroprusside improves circulatory failure in rabbit acute pulmonary embolism combined with shock model possibly by enhancing NO release and inhibiting TLR4/NF-кB/HIF-1α signaling pathway

Sodium nitroprusside (SNP) is a fast-acting non-endothelium-dependent vasodilator, which is commonly used to treat diseases such as hypertensive emergencies and acute heart failure. However, there are few experimental studies evaluating the effects and mechanism of SNP on acute pulmonary embolism. T...

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Bibliographic Details
Main Authors: Yuchan Zhou, Yuting Wang, Delong Yu, Xiaoyan Liu, Wenjuan Cao, Huanhuan Li, Ye Gu, Liqun Hu, Yupeng Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Physiology
Subjects:
acute pulmonary embolism
sodium nitroprusside
TLR4
NF-κB
HIF-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1573405/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1573405/full

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