Crossing the barrier or how regulation of ovastacin controls fertilization and translates into clinical phenotypes

Summary: The zona pellucida, a glycoprotein matrix enveloping the mammalian egg, exerts essential functions during fertilization and early embryonic development. Its safeguard property regulates sperm entry and thus indirectly controls fertility. Limited proteolysis by the metalloproteinase ovastaci...

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Bibliographic Details
Main Authors: Nele von Wiegen, Christian Behl, Hagen Körschgen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012374
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