Effect of administration and withdrawal of the sodium‐glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single‐arm study (RESTORE‐nephropathy study)

Effect of administration and withdrawal of the sodium‐glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single‐arm study (RESTORE‐nephropathy study)

ABSTRACT Aims/Introduction The mechanisms of the renoprotective effects of sodium‐glucose cotransporter 2 inhibitors are unknown. This study aimed to explore the effect and mechanism of tofogliflozin on urinary albumin by administration, withdrawal, and re‐administration. Materials and Methods Indiv...

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Main Authors: Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto, Takatoshi Imai, Akira Yamauchi, Yasuhiko Kanazawa, Toshihide Kawai, Koichiro Azuma, Satoru Yamada, Sho Endo, Hiroshi Itoh, Kaori Hayashi
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of Diabetes Investigation
Subjects:
Diabetic nephropathy
Drug withdrawal
Renal protection
Tofogliflozin
Urinary albumin
Online Access:https://doi.org/10.1111/jdi.70018
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https://doi.org/10.1111/jdi.70018

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