Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging

Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging

Abstract Objective Mitochondrial dysfunction and nuclear epigenetic alterations, two hallmarks of aging, are associated with aberrant development and complex disease risk. Here, we report a method for the simultaneous assessment of mitochondrial DNA copy number (mtDNA-CN) and DNA methylation age (DN...

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Bibliographic Details
Main Authors: Phyo W. Win, Julia Nguyen, Amanda L. Morin, Charles E. Newcomb, Shiva M. Singh, Noha Gomaa, Christina A. Castellani
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Research Notes
Subjects:
Mitochondrial DNA copy number
Epigenetic age
qPCR
Mitochondrial DNA
DNA methylation
Online Access:https://doi.org/10.1186/s13104-023-06673-9
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https://doi.org/10.1186/s13104-023-06673-9

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