Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer’s disease

Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is a multifaceted neurodegenerative disorder with a complex etiology that extends beyond the well-documented amyloid-β and tau pathologies. Growing evidence implicates cerebrovascular dysfunction, particularly brain microvascular endothelial cells (BMECs)...

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Main Authors: Pingao Zhang, Chenghuan Song, Jiyun Shi, Zijie Wei, Jing Wang, Wanying Huang, Rui Zhang, Jintao Wang, Xiaoli Yang, Gang Wang, Xiaoling Gao, Yongfang Zhang, Hongzhuan Chen, Hao Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer's disease
Neurovascular unit
Brain microvascular endothelial cells
Astrocyte
Cerebrovascular endothelial extracellular vesicles
Endoglin
Online Access:https://doi.org/10.1186/s13024-025-00875-4
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https://doi.org/10.1186/s13024-025-00875-4

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