Phenolic Metabolites Protocatechuic Acid and Vanillic Acid Improve Nitric Oxide Bioavailability via the Akt-eNOS Pathway in Response to TNF-α Induced Oxidative Stress and Inflammation in Endothelial Cells

Phenolic Metabolites Protocatechuic Acid and Vanillic Acid Improve Nitric Oxide Bioavailability via the Akt-eNOS Pathway in Response to TNF-α Induced Oxidative Stress and Inflammation in Endothelial Cells

<b>Background/Objectives</b>: Reduced nitric oxide (NO) bioavailability secondary to excess-superoxide-driven oxidative stress is central to endothelial dysfunction. Previous studies suggest that phenolic metabolites may improve NO bioavailability, yet limited research is available in re...

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Bibliographic Details
Main Authors: Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Stephen J. Bailey, Harprit Singh, Mariasole Da Boit
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Metabolites
Subjects:
Cyanidin-3-glucoside
endothelial nitric oxide synthase
nitric oxide
protocatechuic acid
vanillic acid
Online Access:https://www.mdpi.com/2218-1989/14/11/613
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