Granzyme A produced by γ(9)δ(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.

Granzyme A produced by γ(9)δ(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.

Human γ(9)δ(2) T cells potently inhibit pathogenic microbes, including intracellular mycobacteria, but the key inhibitory mechanism(s) involved have not been identified. We report a novel mechanism involving the inhibition of intracellular mycobacteria by soluble granzyme A. γ(9)δ(2) T cells produce...

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Bibliographic Details
Main Authors: Charles T Spencer, Getahun Abate, Isaac G Sakala, Mei Xia, Steven M Truscott, Christopher S Eickhoff, Rebecca Linn, Azra Blazevic, Sunil S Metkar, Guangyong Peng, Christopher J Froelich, Daniel F Hoft
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003119&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003119&type=printable

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