The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons

The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons

Background: Fluorocitrate (FC) ranging from 5 μM to 5 mM is often used as a specific metabolic inhibitor of the astrocytes to study astrocytic functions. Whether FC at such concentrations may affect neuronal metabolism and function <i>in vivo</i> remains unclear. Methods: We examined the...

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Bibliographic Details
Main Authors: Huiling Zhuang, Deliang Yuan, Fuxiu Shi, Xujun Wu, Zhen Luo, Wenbiao Gan
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Brain Sciences
Subjects:
fluorocitrate
astrocyte metabolism
calcium signaling
neuronal calcium activity
synaptic plasticity
Online Access:https://www.mdpi.com/2076-3425/15/2/99
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