SON-dependent nuclear speckle rehabilitation alleviates proteinopathies

SON-dependent nuclear speckle rehabilitation alleviates proteinopathies

Abstract Current treatments targeting individual protein quality control pathways have limited efficacy in alleviating proteinopathies, highlighting the prerequisite for a common druggable target capable of global proteostasis modulation. Building upon our prior research establishing nuclear speckle...

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Main Authors: William Dion, Yuren Tao, Maci Chambers, Shanshan Zhao, Riley K. Arbuckle, Michelle Sun, Syeda Kubra, Matthew A. Schaich, Yuhang Nie, Megan Ye, Imran Jamal, Mads B. Larsen, Daniel Camarco, Eleanor Ickes, Haokun H. Wang, C. DuPont, Bingjie Wang, Silvia Liu, Shaohua Pi, Bennett Van Houten, Bill B. Chen, Yuanyuan Chen, Xu Chen, Bokai Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62242-7
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https://doi.org/10.1038/s41467-025-62242-7

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