Identification and characterization of tertiary lymphoid structures in brain metastases

Identification and characterization of tertiary lymphoid structures in brain metastases

Abstract Brain metastases (BrM) are the most common cancers in the brain and linked to poor prognosis. Given the high incidence and often limited treatment options, understanding the complexity of the BrM tumor microenvironment is crucial for the development of novel therapeutic strategies. We perfo...

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Main Authors: Sadaf S. Mughal, Yvonne Reiss, Jörg Felsberg, Lasse Meyer, Jadranka Macas, Silja Schlue, Tatjana Starzetz, Karl Köhrer, Tanja Fehm, Volkmar Müller, Katrin Lamszus, Dirk Schadendorf, Iris Helfrich, Harriet Wikman, Anna Berghoff, Benedikt Brors, Karl H. Plate, Guido Reifenberger
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Brain metastasis
Immune cell deconvolution
Multiplex immunofluorescence
Tertiary lymphoid structures
Tumor microenvironment
Online Access:https://doi.org/10.1186/s40478-025-02007-x
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https://doi.org/10.1186/s40478-025-02007-x

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