High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Abstract Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associated TREM2 variants to various forms of Aβ and A...

Full description

Saved in:
Bibliographic Details
Main Authors: Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Format: Article
Language:English
Published: Springer Nature 2018-10-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
amyloid
APOE
innate immune response
TREM2
Online Access:https://doi.org/10.15252/emmm.201809027
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.15252/emmm.201809027

Similar Items