Sequencing validates deep learning models for EHR-based detection of Noonan syndrome in pediatric patients

Abstract Despite advanced diagnostic tools, early detection of rare genetic conditions like Noonan syndrome (NS) remains challenging. We evaluated a deep learning model’s real-world performance in identifying potential NS cases using electronic health record (EHR) data, validated through genetic seq...

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Bibliographic Details
Main Authors: Zeyu Yang, Amy Shikany, Ammar Husami, Xinjian Wang, Eneida Mendonca, K. Nicole Weaver, Jing Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-025-00512-5
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