Divergent immediate and delayed effects of juvenile exposure to doxorubicin on the thymus in C57BL/6 mice

Divergent immediate and delayed effects of juvenile exposure to doxorubicin on the thymus in C57BL/6 mice

Abstract The long-term effects of doxorubicin (DOX) chemotherapy on thymic immune function in childhood cancer survivors remain inadequately understood. This study explores the immediate and delayed impacts of low-dose DOX on thymic immune populations using a juvenile mouse model. Male mice received...

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Main Authors: Benu George, Korbyn J. V. Dahlquist, Marianne K. O. Grant, Mary R. Daniel, Declan M. Smith, Ian Ahlberg, Karim T. Sadak, Davis Seelig, Christina D. Camell, Beshay N. Zordoky
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Doxorubicin
Immune cells
Thymus
Senescence
T-cells
Thymocytes
Online Access:https://doi.org/10.1038/s41598-025-98617-5
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https://doi.org/10.1038/s41598-025-98617-5

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