Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism

Abstract Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanis...

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Bibliographic Details
Main Authors: Haitao Pan, Congshu Li, Mengyao Wang, Kang Ye, Xiaohui Fan, Yongping Fu, Jihong Yang, Zhenhao Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sporoderm-removed Ganoderma lucidum spores
Osteosarcoma
Glycerophospholipid metabolism
Fatty acid metabolism
Multi-omics analysis
Online Access:https://doi.org/10.1038/s41598-025-05890-5
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https://doi.org/10.1038/s41598-025-05890-5

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