TRIOL attenuates intracerebral hemorrhage injury by bidirectionally modulating microglia- and neuron-mediated hematoma clearance

TRIOL attenuates intracerebral hemorrhage injury by bidirectionally modulating microglia- and neuron-mediated hematoma clearance

Intracerebral hemorrhage (ICH) represents the most severe subtype of stroke, and the lack of effective clinical pharmacotherapies poses a substantial threat to human health. Hematoma plays a crucial role in determining the prognosis of ICH patients by causing primary mechanical extrusion, followed b...

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Main Authors: CaiLv Wei, Chen Chen, ShengLong Li, YuXuan Ding, YuWei Zhou, FangYing Mai, ShiRan Hong, JiaXin Wu, Yang Yang, Zhu Zhu, DongDong Xue, XinPeng Ning, LongXiang Sheng, BingZheng Lu, Wei Cai, MingJun Yuan, HuaFeng Liang, SuiZhen Lin, GuangMei Yan, YuPin Chen, YiJun Huang, Cheng Hu, Wei Yin
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Redox Biology
Subjects:
Intracerebral hemorrhage
TRIOL
Hematoma clearance
Heme oxygenase 1
Heme oxygenase 2
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004658
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