NSDHL contributes to breast cancer stem-like cell maintenance and tumor-initiating capacity through TGF-β/Smad signaling pathway in MCF-7 tumor spheroid

NSDHL contributes to breast cancer stem-like cell maintenance and tumor-initiating capacity through TGF-β/Smad signaling pathway in MCF-7 tumor spheroid

Abstract Background NAD(P)-dependent steroid dehydrogenase-like protein (NSDHL), which is involved in breast tumor growth and metastasis, has been implicated in the maintenance of cancer stem cells. However, its role in regulating breast cancer stem-like cells (BCSCs) remains unclear. We have previo...

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Main Authors: So-Hyun Yoon, Sangeun Lee, Hoe Suk Kim, Junhyuk Song, Moonjou Baek, Seungyeon Ryu, Han-Byoel Lee, Hyeong-Gon Moon, Dong-Young Noh, Sangyong Jon, Wonshik Han
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Cancer
Subjects:
NSDHL
MCF-7 human breast cancer cell
Tumor spheroid
Cancer stem cell
Cholesterol
TGF-β
Online Access:https://doi.org/10.1186/s12885-024-13143-3
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https://doi.org/10.1186/s12885-024-13143-3

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