Vasodilator Effects of Quercetin 3-O-Malonylglucoside Are Mediated by the Activation of Endothelial Nitric Oxide Synthase and the Opening of Large-Conductance Calcium-Activated K<sup>+</sup> Channels in the Resistance Vessels of Hypertensive Rats

Vasodilator Effects of Quercetin 3-O-Malonylglucoside Are Mediated by the Activation of Endothelial Nitric Oxide Synthase and the Opening of Large-Conductance Calcium-Activated K<sup>+</sup> Channels in the Resistance Vessels of Hypertensive Rats

We used molecular docking as a computational tool to predict the binding affinities and interactions of quercetin 3-O-malonylglucoside (Q3MG) with vascular target proteins. First, the proteins 1M9M (human endothelial nitric oxide synthase; eNOS) and 6ND0 (human large-conductance voltage- and calcium...

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Bibliographic Details
Main Authors: Maria Luiza Fidelis da Silva, Erdi Can Aytar, Arquimedes Gasparotto Junior
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
flavone
mesenteric vascular bed
K<sup>+</sup> channels
vasodilation
Online Access:https://www.mdpi.com/1420-3049/30/13/2867
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