IDO‐1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension

IDO‐1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension

Background Activation of the plasma kynurenine pathway (KP) may contribute to the progression of pulmonary arterial hypertension (PAH). We investigated the functional role and molecular mechanisms of KP activation in PAH. Methods KP activity was measured in the lungs and plasma of humans and rodents...

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Main Authors: Zongye Cai, Ly Tu, Siyu Tian, Lin Deng, Yahong Fu, Carole Phan, Thierry P. P. van den Bosch, Karin Tran‐Lundmark, Bence M. Nagy, Horst Olschewski, Xiaoxuan Li, Sihao Wang, Danan Wang, Yi Yan, Lijun Fu, Karin A. Boomars, Christophe Guignabert, Daphne Merkus
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
indoleamine 2,3‐dioxygenase (IDO‐1)
kynurenine pathway
nicotinamide adenine dinucleotide
pulmonary arterial hypertension
pulmonary vascular remodeling
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.040896
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https://www.ahajournals.org/doi/10.1161/JAHA.124.040896

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