Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones

Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones

Summary: Clonal fitness and plasticity drive cancer heterogeneity. We used expressed lentiviral-based cellular barcodes combined with single-cell RNA sequencing to associate single-cell profiles with in vivo clonal growth. This generated a significant resource of growth measurements from over 20,000...

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Main Authors: Long V. Nguyen, Yaniv Eyal-Lubling, Daniel Guerrero-Romero, Sarah Kronheim, Suet-Feung Chin, Raquel Manzano Garcia, Stephen-John Sammut, Giulia Lerda, Allan J.W. Lui, Helen A. Bardwell, Wendy Greenwood, Hee Jin Shin, Riccardo Masina, Katarzyna Kania, Alejandra Bruna, Elham Esmaeilishirazifard, Emily A. Kolyvas, Samuel Aparicio, Oscar M. Rueda, Carlos Caldas
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500470X
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http://www.sciencedirect.com/science/article/pii/S221112472500470X

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