Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502

Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502

Streptomyces sp. MJM3502 is a promising producer of rufomycins, which are a class of potent anti-tuberculosis lead compounds. Although the structure, activity, and mechanism of the main rufomycin 4/6 and its analogs have been extensively studied, a significant gap remains in our understanding of the...

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Bibliographic Details
Main Authors: Chun Su, Nguyen-Quang Tuan, Wen-Hua Li, Jin-Hua Cheng, Ying-Yu Jin, Soon-Kwang Hong, Hyun Lee, Mallique Qader, Larry Klein, Gauri Shetye, Guido F. Pauli, Scott G. Flanzblau, Sang-Hyun Cho, Xin-Qing Zhao, Joo-Won Suh
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
Anti-Tuberculosis
Streptomyces sp. MJM3502
Rufomycin
Genome mining
Promoter engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X2500002X
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