UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia

UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia

Abstract The prognosis for adult B-cell acute lymphoblastic leukemia remains unfavorable, especially in the context of relapsed and refractory disease. Exploring the molecular mechanisms underlying disease progression holds significant promise for improving clinical outcomes. In this investigation,...

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Main Authors: Yan Huang, Luting Luo, Yangqi Xu, Jiazheng Li, Zhengjun Wu, Chenxing Zhao, Jingjing Wen, Peifang Jiang, Haojie Zhu, Lingyan Wang, Yanxin Chen, Ting Yang, Jianda Hu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07532-0
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https://doi.org/10.1038/s41419-025-07532-0

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